AOD9604
CAS No.:221231-10-3
Storage Temp:Please seal and store at 8°C–20°C
WARNING: This product is for research use only.
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Product Name: | AOD9604 |
CAS number: | 221231-10-3 |
Molecular Formula: | C78H123N23O23S2 |
Molecular Weight: | 1815.10 |
Sequence: | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe |
Other names/Synonyms: | Fragment177-191,AOD9604acetate,PeptideHGH176-191,HGHfrag176-191Oxidized |
Storage Temp: | Please seal and store at 8°C–20°C |
Noted: Please refer to Certificate of Analysis for more information of peptide AOD9604.
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1.What Is AOD9604?
AOD9604 is a peptide fragment of human growth hormone (hGH) with oral activity, derived from the C-terminal region of HGH. It consists of amino acid residues 176-191 of HGH, with the phenylalanine at the C-terminus replaced by tyrosine. Human trials have shown that AOD9604 retains the fat-burning properties of human growth hormone but does not stimulate the production of IGF-1. Originally developed as an anti-obesity drug, AOD9604 is believed to have the ability to promote the breakdown of fat cells and facilitate weight loss.
2.How Does AOD9604 Work?
AOD9604 is believed to work by simulating the fat-burning properties of human growth hormone (hGH) while avoiding excessive production of insulin-like growth factor-1 (IGF-1). It primarily targets fat tissue, stimulating the breakdown of fat cells and releasing fatty acids into the bloodstream, thereby promoting the utilization of fat for energy. Unlike full hGH, AOD9604 is designed not to stimulate the release of IGF-1, thus avoiding some of the adverse effects associated with excessive growth hormone activity. What is extraordinary about the AOD9604 is its ability to reduce abdominal fat stores.
Another highly effective fat burning peptide is CJC-1295, as it leads to an overall increase in GH levels in the body (contrary to what typically happens with age). If your sole goal when using peptides from Aea.ltd is fat loss, try to avoid using GHRP-6, GHRP-2, or GHRH products, as they may increase hunger and cortisol levels. A benefit of AOD9604 is that it does not increase hunger or raise cortisol levels.
3.AOD9604 Potential Benefits
AOD9604 plays a key role in regulating fat metabolism with its characteristics of stimulating fat breakdown and inhibiting fat production. Its mechanism of action helps to increase weight loss efficiency and promote the fat loss process. AOD9604 specifically targets excess body fat, triggering fat release from fat cells without negatively affecting blood sugar levels or stimulating excessive tissue growth. Scientific research has fully demonstrated the powerful and effective fat-burning properties of AOD9604, highlighting its role in promoting weight loss and reducing body fat. AOD9604 has also been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.
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4.AOD9604 Side Effects
Here were some of the most commonly reported AOD-9604 side effects, with none of them being severe:
- Headache
- Fatigue
- Dizziness
- Cough
- Mild to moderate euphoria
- Chest construction/tightness
- Palpitations
- Nasopharyngitis
- Swelling, bruising, itching, and/or redness at the injection site (where relevant)
However, while AOD9604 is a very safe fat burning peptide with rare and mild side effects, for your health and safety, you should still pay attention to its quality when purchasing and using AOD9604,please make sure the powder you purchase meets high quality standards. Aea.ltd is committed to providing you with high quality Tirzepatide powder to minimize potential side effects.
5.AOD9604 VS HGH Frag 176-191
AOD-9604 and HGH Frag 176-191 are both peptide fragments derived from human growth hormone (HGH) and are commonly used for fat loss and body shaping. There are some similarities between them, but there are some differences in structure, function and research.
Similarity:
- Source: All derived from the C-terminal domain of human growth hormone (HGH).
- Target: Both target specific segments of fat metabolism. They help reduce fat and improve body composition by promoting lipolysis and fat oxidation.
- Potential effects: All may have the effects of promoting fat burning and increasing muscle growth, and are helpful for weight management, especially for those who want to lose fat and maintain muscle.
Difference:
Feature | AOD 9604 | HGH Frag 176-191 |
Structure | Derivative of the C-terminal domain of human growth hormone (HGH), containing amino acid residues 176-191 and having a tyrosine instead of phenylalanine at the C-terminus | Fragment of the C-terminal domain of HGH, containing amino acid residues 176-191 |
Activity | Orally active | Parenterally active |
Mechanism | May promote fat burning by activating beta3-adrenergic receptors in adipocytes | May work through multiple mechanisms, including promoting fat burning, increasing muscle growth, and improving bone health |
Research | There are few studies, mainly focusing on animal models | Relatively many studies, including some human studies |
Side effect | May include headache, nausea, and injection site pain | May include headache, nausea, and injection site pain |
Legal status | In the United States, AOD 9604 is not approved for any medical use and is classified as a dietary supplement. The legal status of AOD 9604 may vary in other countries | HGH Frag 176-191 is classified as a prescription drug in most countries |
Selection suggestions:
- Personal Goals: Choosing which peptide to use depends on your personal health goals. If your main goal is fat loss, either of these peptides may be a suitable choice. Also, understand that individuals may respond differently to different peptides, so be sure to conduct adequate research before using any new medication or supplement and use it under the guidance of a medical professional.
- Safety considerations: Although these peptides are generally considered relatively safe, there may still be potential side effects and risks. Before considering use, its safety should be evaluated and used only at appropriate dosages and circumstances.
- Quality and Source: It is crucial to choose high-quality products and trustworthy suppliers to ensure that you are using a pure and safe product. Aea.ltd currently offers the best quality AOD9604, and if AOD9604 is your final choice, Aea.ltd is a reliable source worth trying.
6.AOD9604 Vs. Semaglutide
AOD-9604 and Semaglutide are two substances with different mechanisms of action used for weight management. Here are their main differences:
Feature | AOD-9604 | Semaglutide |
Type | Peptide (Growth Hormone Fragments) | Glucagon-like peptide-1 (GLP-1) receptor agonist |
Mechanism | Simulates the effects of growth hormone-releasing hormone (GHRH) in the human body, thereby promoting fat burning and reducing fat storage | Mimics the effects of glucagon-like peptide-1 (GLP-1), increasing insulin secretion, lowering blood sugar levels, thereby reducing appetite, increasing satiety and slowing gastric emptying |
Weight loss effect | Considered to help reduce fat deposits and increase metabolic rate, it is primarily used for weight loss and body fat regulation. | FDA approved for weight loss, with proven effectiveness in promoting weight loss in clinical trials. |
Safety | Headache, nausea, and injection site pain may occur. | Known side effects include nausea, vomiting, diarrhea, and constipation and are generally well tolerated. |
Suggestions:
If your main goal is fat loss and you are in good health, AOD9604 may be an option.
If you have type 2 diabetes or obesity and are seeking weight loss, semaglutide may be a more suitable option, especially if used under a doctor’s supervision.
No matter which drug you choose, you should use it under the guidance of a doctor and understand the possible side effects and risks.
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7.Why AOD9604 + Semaglutide Is The Best Fat Loss Peptide Stack?
Semaglutide effectively regulates blood sugar levels by delaying gastric emptying and promoting insulin secretion. Stabilized blood sugar levels reduce the body’s tendency to convert excess calories into fat.
Meanwhile, AOD 9604 promotes lipolysis and inhibits lipogenesis. What’s more, AOD 9604 does not cause blood sugar fluctuations, so you can enjoy the benefits of an active metabolism without the risks.
As a result, combining Semaglutide with AOD 9604 synergistically enhances fat burning and fat loss, making it an ideal muscle growth and weight loss peptide stacking solution.
In addition to this option, there are two other excellent fat loss peptide stacks:
①Tesamorelin+Ipamorelin
Tesamorelin acts primarily on the pituitary gland to stimulate the release of growth hormone (GH). GH in turn triggers a series of effects that enhance metabolism, increase fat burning and promote muscle growth. Ipamorelin acts directly on the hypothalamus, another key regulator of GH secretion. It enhances the sensitivity of hypothalamus to GHRP and enhances the GH releasing effect of Tesamorelin. The combination of Tesamorelin and Ipamorelin effectively promotes fat loss by increasing the level of GH, which enhances the metabolism, promotes fat burning, promotes muscle growth, and may regulate the appetite, thus making it a good partner for fat loss.
②CJC-1295 without DAC +Ipamorelin
CJC-1295 without DAC is a growth hormone-releasing peptide (GHRP) whose mechanism of action involves stimulation of the GHRP receptor, leading to an increase in intracellular calcium ion levels. This process activates intracellular signaling pathways that ultimately contribute to increased secretion of growth hormone (GH).
Ipamorelin, on the other hand, is a growth hormone-releasing hormone (GHRH) whose action involves the stimulation of GHRH receptors, also leading to an increase in GH secretion.
As with the previous pairing, it is all due to the effects of GH that they are a favorite among many fitness and fat loss individuals.
To summarize, no matter which of the above fat loss peptide stacks you choose, you will get significant fat loss results. Choosing the right peptide combination for you depends largely on your personal needs and preferences. You can choose any of the combinations on the Aea.ltd website to start your fat loss journey.
8.What Are The Advantages Of AOD9604 Compared To Other Weight Loss Drugs?
- Specific target: AOD9604 promotes lipolysis by simulating the action of GHRH, mainly acting on adipocytes. This specific target of action makes it more focused than other weight loss drugs and does not affect other tissues or systems, such as the cardiovascular system or the central nervous system.
- Biological activity stability: The biological activity of AOD9604 is relatively stable and can maintain its effect in the body for a long time. Compared with some weight-loss drugs that require frequent administration or have short-lived effects, AOD9604 can provide a more lasting fat-reducing effect and help maintain a stable weight.
- Relative safety: AOD9604 is considered relatively safe, and clinical trials and studies have shown that there are no serious side effects at recommended doses. AOD9604 has a lower risk of side effects than some other weight loss drugs, such as some appetite suppressants or metabolism accelerators.
- Wide range of application: AOD9604 is suitable for people who are generally overweight or mildly obese. It is not only suitable for people who need to lose weight, but also for people who want to improve body fat distribution and metabolism.
9.How Is The Fat Reduction Effect Of AOD9604?
Index | Data Sources | The data shows |
Weight loss | In a randomized double-blind controlled trial, a total of 120 overweight or obese subjects were randomly divided into the AOD9604 group and the placebo group, 500 mg twice a day for 12 weeks. | The average weight loss in the AOD9604 group was 8.8 kg, and the average weight loss in the placebo group was 2.2 kg. |
Reduced body fat percentage | Same as above | The average body fat rate of the AOD9604 group decreased by 7.6%, and the average body fat rate of the placebo group decreased by 2.1%. |
Waist circumference reduction | Same as above | The average waist circumference decreased by 5.8 cm in the AOD9604 group and 2.4 cm in the placebo group. |
Reduced subcutaneous fat thickness | Same as above | The average subcutaneous fat thickness decreased by 1.2 cm in the AOD9604 group and by 0.5 cm in the placebo group. |
Reduction in visceral fat area | Same as above | The average visceral fat area decreased by 15.2 cm² in the AOD9604 group and 6.8 cm² in the placebo group. |
Other research results show:
1.AOD9604 can significantly reduce total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides and blood glucose levels.
2.AOD9604 can significantly increase high-density lipoprotein cholesterol (HDL-C) levels.
3.AOD9604 can improve insulin sensitivity.
4.AOD9604 can reduce inflammatory marker levels.
10.Where To Buy AOD9604 ?
Aea.ltd is your best choice when shopping online. Aea.ltd focuses on providing high-quality AOD9604 raw powder and lyophilized powder in vial. In both forms we guarantee the highest quality AOD9604 products. To ensure your safety, we recommend that you carefully screen and compare extensively to ensure that the choice you make is as reliable as Aea.ltd.
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AOD 9604 peptide, also called the fat-burning peptide, is a reconstructed form of the amino acids 176-191. Once taken, this peptide stimulates the pituitary gland, mimicking the human growth hormone and speeding up the body’s metabolism. Once metabolism is regulated, body will start to burn fat at a quicker rate.
Since many peptides remain outside the regulation of the FDA, it’s not always easy finding a legitimate source. Customers need to verify that they are purchasing AOD9604 injections from a trustworthy peptide supplier that can confirm the purity and consistency of each batch. It’s wise to only buy peptides from a reputable AOD9604 manufacturer.
Pharmaceutical grade AOD9604 vials and AOD9604 powder that is manufactured by top peptide manufacturer Aea.ltd are easily available. Aea.ltd as the best AOD9604 peptide manufacturer, produces AOD9604 injections and AOD9604 raw powder according to cGMP standards strictly, equipped with HPLC, GC, and other analytical instruments. Tests can be done on IR, GC/MS, LC/MS and 400NMR at the SIOC through contract. QA Operations have been in place for several years to ensure that products at our company are prepared responsibly and in accordance with ISO 9001 standards. It’s why Aea.ltd is considered the best place to buy AOD 9604 peptide.
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Aea.ltd is the professional manufacturer of AOD9604 to produce top quality peptide AOD9604 pure raw powder and Semi finished AOD9604 in vial, both form can accept customized service. The production capacity is stable, our factory will confirm the quality standard before sell, make sure all AOD9604 powder and Semi finished AOD9604 which sell to clients is conform the quality standard. We also welcome our clients to test this 2 forms of our AOD9604 at anytime. Here are some testing reports of AOD9604 in Lyophilized powder for reference:
1.Certificate of Analysis-AOD9604 Lyophilized Powder (CAS: 221231-10-3)
What is COA and What does COA tell you?
A certificate of analysis (CoA) is an essential document in chemical distribution that outlines all the tests performed on a product before it is shipped to a customer. The Certificate of Analysis (CoA) is a contractual document most often issued by a quality control department. It serves to confirm with evidence (analysis results) that a product is tested according to certain standards and methods, and that test results are available.
2.HPLC Report-AOD9604 Lyophilized Powder (CAS: 221231-10-3)
What is HPLC and What does HPLC tell you?
High-performance liquid chromatography (HPLC) is an analytical chemistry technique for separate mixture, quantitative analysis, purity detection and structural identification, this utilize the pressure-driven flow of a mobile phase through a column packed with a stationary phase. The compounds separated in the column are detected by a detector downstream of the column and each compound is identified and quantified. HPLC is widely used in food, chemicals, pharmaceuticals,biological, environmental and agriculture.
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Aea.ltd is the professional manufacturer of the best AOD9604 , our factory produce high quality peptide AOD9604 raw powder and provide customized service on finished vial of AOD9604 , we welcome many requesters and buyers of pure AOD9604 bulk powder to contact us! Individual users should avoid buying bulk AOD9604 powder. The advantages of wholesale AOD9604 products from Aea.ltd include:
❶Factory production on a large scale, consistent supply, a short delivery cycle, and high price competitiveness;
❷Provide a quality assurance report for the corresponding batch of quality test report.
❸Professional logistics customization solutions, on-time delivery;
❹Payment methods that are diverse, such as TT and virtual currency;
❺High-quality pre-sales and after-sales service, followed by product and order details consultation.
1.How to get the quick quote of AOD9604 online?
Visit professional AOD9604 supplier in China-Aea.ltd website, choose the AOD9604 you want, and leave your contact and message on Aea.ltd website, then submit Aea.ltd. The customer service will reply you in 12 hours once received your message,then talk in details about AOD9604 products.
2.Does Aea.ltd support the free sample of AOD9604 powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for free sample. Welcome our clients test our top quality AOD9604 powder at any time!
3.What form of AOD9604 can I buy from Aea.ltd?
Welcome to order AOD9604 from professional peptide manufacturer Aea.ltd! We can provide 2 forms AOD9604, the one is AOD9604 pure raw powder, another is AOD9604 lyophilized powder in vial. Our clients can buy AOD9604 from Aea.ltd according to your requests.
4.Can we appoint the cap color of the AOD9604 injection if we buy AOD9604 from Aea.ltd?
Yes, Aea.ltd is the professional peptide manufacturer and also provide CDMO service, accept the request of clients on cap color and our clients can appoint the cap color of AOD9604 if you have bulk order on AOD9604 vials.
5.Can we buy different specification of AOD9604 injection from Aea.ltd?
Sure, Aea.ltd peptide factory always produce different specification of AOD9604 in term according to the request of market. Our clients can buy AOD9604 5mg, 10mg, 15mg…. from us.
6.How is the AOD9604 packaging? Will the bottle break during shipment?
Aea.ltd, as a professional peptide AOD9604 factory, offers professional packages on all products and adheres to stringent packaging requirements. We package each AOD9604 vial in separate compartments, with 10 in a box to ensure that they do not come into contact with each other during shipment. We also use vacuum packaging to avoid damage caused by shaking and protect the product as much as possible. Furthermore, we accept customized packaging services based on the needs of our customers.
7.Can I buy discount AOD9604 powder from Aea.ltd?
Sure, our factory produce high quality AOD9604 powder in term and keep AOD9604 powder in stock. The more you buy, the more cheaper your price will be. In addition, our company also has planned promotions on bulk AOD9604 powder every year. You can buy high quality AOD9604 powder by lower price during promotion sale. You can keep touch with our customer manager and they will update the latest bulk AOD9604 powder price for you in time.
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You Might Also Be Concerned About These Issues:
1.Does AOD9604 work? |
2.What is the most powerful peptide for fat loss? |
3.What is AOD9604 used for? |
4.Does AOD9604 increase growth hormone levels? |
5.Can AOD9604 be used for muscle growth? |
6.where can I buy high quality AOD9604 online? |
7.Is AOD9604 safe for long-term use? |
8.Can AOD9604 be used without exercise or diet changes? |
9.How is AOD9604 administered? |
10.Who cannot use AOD9604? |
11.Is hGH Frag 176 191 the same as AOD9604? |
12.Is AOD9604 legal? |
As for these questions, please go to the offical website of original drug and see full Prescribing Information and Medication Guide, especially for personal use, please use AOD9604 under the guide of doctor.
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[1]Ng, F., Natera, S., Jiang, W.-J. US Patent No. 5,869,452 (1999).
[2]Ng, F., Jiang, W.-J. Int. Patent Appl. PCT/AU98/00724. Published and grant pending.
[3]Human growth hormone. Br Med J. 1967;2(5544):64-65.
[4]Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7) e0181748.
[5]Demling RH. Nutrition, anabolism, and the wound healing process: an overview. Eplasty. 2009;9:e9.
[6]Seton-Rogers S. Metabolism: Catabolic effects [published correction appears in Nat Rev Cancer. 2012 Feb;12(2):83]. Nat Rev Cancer. 2011;11(11):757. Published 2011 Oct 24. doi:10.1038/nrc3161 .
[7]The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and β3-AR knock-out mice. / Heffernan, Mark; Summers, Roger J.; Thorburn, Anne; Ogru, Esra; Gianello, Robert; Jiang, Woei Jia; Ng, Frank M.
[8] Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278. doi:10.1159/000053183
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