Cibinetide

Noted: Please refer to Certificate of Analysis for more information of peptide Cibinetide.

1.What Is Cibinetide (ARA-290)?

Cibinetide, also known as ARA 290 and helix B surface peptide (HBSP), is a synthetic 11-mer peptide that interacts to the tissue-protective receptor. ARA290 is also an EPO derivative, a specific erythropoietin/CD131 heteroreceptor agonist, and is often used in the treatment of neurological diseases.Cibinetide (ARA 290) is an engineered peptide that mimics the 3 dimensional structure of the helix B surface domain of erythropoietin (EPO). It is designed to bind selectively to the non-hematopoietic EPO receptor (sometimes referred to as the innate repair receptor or IRR), that is believed to be a heterodimer of EPOR and the cytokine family beta common receptor (βCR, CD131). Non-hematopoietic EPO ligands have potential tissue protective and anti-inflammatory actions. The IRR is suggested to be a point of integration between the immune system and pain signalling (via nociception).

2.How Does Cibinetide Work?

While most of us experience appropriately functioning inflammation elevation (which is required for regular physical activities), our bodies struggle with reducing inflammation. Instead of temporarily suppressing inflammation with NSAIDs, Cibinetide peptide can truly resolve it. It accomplishes this by activating your body’s natural repair system via the Innate Repair Receptor and inhibiting systemic inflammation.

3.What Is The Potential Benefits?

Cibinetide is a synthetic 11 amino acid peptide generated from the B helix of erythropoietin (EPO), having potent anti-apoptotic, anti-inflammatory, and anti-permeability properties that mimic the actions of endogenous EPO. Unlike EPO, it is not haematopoietic, hence it is not subject to the potentially fatal side effects of EPO. In a DR experimental model, systemic administration of cibinetide prevented vascular leakage and edema while protecting retinal blood vessels and neuroglial degeneration. Furthermore, cibinetide enhanced metabolic regulation in both preclinical and clinical trials.

4.Where To Buy Cibinetide (ARA290) Online?

Aea.ltd is your best choice when shopping Cibinetide(ARA290) online. Aea.ltd focuses on providing high-quality Cibinetide raw powder and lyophilized powder in vial. In both forms we guarantee the highest quality Cibinetide products. To ensure your safety, we recommend that you carefully screen and compare extensively to ensure that the choice you make is as reliable as Aea.ltd.

Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for neurological disease treatment.

As the best peptide manufacturer, Aea.ltd strictly adheres to cGMP standards and is equipped with advanced analytical instruments such as HPLC and GC. Our factory has multiple standard production reactors and freeze dryers, accept the customized service on  synthetic peptide Cibinetide (ARA290).

We always advise readers to get Cibinetide vials and Cibinetide raw powder from reliable peptide suppliers, as these tend to follow strict health and safety rules which makes Cibinetide more reliable and safer. Welcome to contact with us for more details about Cibinetide (ARA290).

Aea.ltd is the professional manufacturer of Cibinetide to produce top quality peptide Cibinetide pure raw powder and Semi finished Cibinetide in vial, both form can accept customized service. The production capacity is stable, our factory will confirm the quality standard before sell, make sure all Cibinetide powder and Semi finished Cibinetide which sell to clients is conform the quality standard. We also welcome our clients to test this 2 forms of our Cibinetide at anytime. Here are some testing reports of Cibinetide in Lyophilized powder for reference:

1.Certificate of Analysis-Cibinetide Lyophilized Powder (CAS: 1208243-50-8)

COA-Cibinetide Lyophilized Powder (CAS 1208243-50-8)

What is COA and What does COA tell you?

A certificate of analysis (CoA) is an essential document in chemical distribution that outlines all the tests performed on a product before it is shipped to a customer. The Certificate of Analysis (CoA) is a contractual document most often issued by a quality control department. It serves to confirm with evidence (analysis results) that a product is tested according to certain standards and methods, and that test results are available.

2.HPLC Report-Cibinetide Lyophilized Powder (CAS: 1208243-50-8)

What is HPLC and What does HPLC tell you?

High-performance liquid chromatography (HPLC) is an analytical chemistry technique for separate mixture, quantitative analysis, purity detection and structural identification, this utilize the pressure-driven flow of a mobile phase through a column packed with a stationary phase. The compounds separated in the column are detected by a detector downstream of the column and each compound is identified and quantified. HPLC is widely used in food, chemicals, pharmaceuticals,biological, environmental and agriculture.

Aea.ltd is the professional manufacturer of the best Cibinetide, our factory produce high quality peptide Cibinetide raw powder and provide customized service on finished vial of Cibinetide, we welcome many requesters and buyers of pure ARA290 bulk powder to contact us! Individual users should avoid buying bulk Cibinetide powder. The advantages of wholesale Cibinetide products from Aea.ltd include:

❶Factory production on a large scale, consistent supply, a short delivery cycle, and high price competitiveness;

❷Provide a quality assurance report for the corresponding batch of quality test report.

❸Professional logistics customization solutions, on-time delivery;

❹Payment methods that are diverse, such as TT and virtual currency;

❺High-quality pre-sales and after-sales service, followed by product and order details consultation.

1. How to get the quick quote of Cibinetide (ARA290) online?

Visit professional Cibinetide supplier in China-Aea.ltd website, choose the Cibinetide/ARA-290 you want, and leave your contact and message on Aea.ltd website, then submit Aea.ltd. The customer service will reply you in 12 hours once received your message,then talk in details about Cibinetide products.

2. Does Aea.ltd support the free sample of Cibinetide powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for free sample. Welcome our clients test our top quality Cibinetide powder at any time!

3.What form of Cibinetide can I buy from Aea.ltd?

Welcome to order Cibinetide(ARA290) from professional peptide manufacturer Aea.ltd! We can provide 2 forms Cibinetide, the one is Cibinetide pure raw powder, another is Cibinetide lyophilized powder in vial. Our clients can buy Cibinetide from Aea.ltd according to your requests.

4.Can we appoint the cap color of the Cibinetide injection if we buy Cibinetide from Aea.ltd?

Yes, Aea.ltd is the professional peptide manufacturer and also provide CDMO service, accept the request of clients on cap color and our clients can appoint the cap color of Cibinetide if you have bulk order on Cibinetide vials.  

5.Can we buy different specification of Cibinetide injection from Aea.ltd?

Sure, Aea.ltd peptide factory always produce different specification of Cibinetide in term according to the request of market. Our clients can buy Cibinetide 5mg, 10mg, 15mg…. from us.

6.How is the Cibinetide packaging? Will the bottle break during shipment?

Aea.ltd, as a professional peptide Cibinetide factory, offers professional packages on all products and adheres to stringent packaging requirements. We package each Cibinetide vial in separate compartments, with 10 in a box to ensure that they do not come into contact with each other during shipment. We also use vacuum packaging to avoid damage caused by shaking and protect the product as much as possible. Furthermore, we accept customized packaging services based on the needs of our customers.

7. Can I buy discount Cibinetide/ARA290 powder from Aea.ltd?

Sure, our factory produce high quality Cibinetide powder in term and keep ARA290 powder in stock. The more you buy, the more cheaper your price will be. In addition, our company also has planned promotions on bulk Cibinetide/ARA290 powder every year. You can buy high quality Cibinetide powder by lower price during promotion sale. You can keep touch with our customer manager and they will update the latest bulk Cibinetide powder price for you in time.

You Might Also Be Concerned About These Issues:

As for these questions, please go to the offical website of original drug and see full Prescribing Information and Medication Guide, especially for personal use, please use Cibinetide(ARA290) under the guide of doctor.

[1]Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand.[J]. Transplantation, 2020. DOI:10.1097/TP.0000000000003284.

[2]Zamzam Awida, et al. The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.

[3] LOISNOEMI. A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.[J]. Journal of Clinical Medicine, 2020. DOI:10.3390/jcm9072225.

[4] NAIRZMANFRED. Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.[J]. Scientific Reports, 2017. DOI:10.1038/s41598-017-13046-3.

[5] BRINESMICHAEL CeramiAnthony. The receptor that tames the innate immune response.[J]. Molecular Medicine, 2012. DOI:10.2119/molmed.2011.00414.

[6] Manfred Nairz, et al. Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis

[7] BRINESMICHAEL CeramiAnthony. Erythropoietin and engineered innate repair activators.[J]. Methods in molecular biology, 2013. DOI:10.1007/978-1-62703-308-4_1.

[8] Noemi Lois. “A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema.” Journal of Clinical Medicine (2020).