Letrozole powder
Other names: Raw Femara powder
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Product Name: | Letrozole powder |
CAS number: | 112809-51-5 |
Molecular Formula: | C17H11N5 |
Molecular Weight: | 285.31g/mol |
Melt Point: | 181-183°C |
Purity: | > 98% |
Appearance: | White or off white crystalline powder |
Storage Temp: | RT |
Noted: Please refer to Certificate of Analysis for more information of Letrozole(Femara) powder.
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1.What is PCT letrozole?
Letrozole is a potent medication known for its role as an aromatase inhibitor, primarily used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. Approved by the United States Food and Drug Administration (FDA) and marketed under the brand name Femara, letrozole works by blocking the enzyme aromatase, which converts androgens into estrogens. By significantly reducing estrogen levels, letrozole helps slow or stop the growth of estrogen-dependent cancer cells. Beyond its primary use, letrozole has gained attention for its off-label applications, including fertility treatments where it induces ovulation, and in bodybuilding, where it aids in managing estrogen levels and supporting the recovery of natural testosterone production in post-cycle therapy (PCT). This versatile drug continues to be a subject of extensive research and interest across various medical and non-medical fields.
2.Letrozole powder
The generic form of Femara is called letrozole. In terms of medical effectiveness, Femara (brand name) and generic letrozole are considered equivalent. This means that both Femara and generic letrozole contain the same active ingredient letrozole powder at the same strength and are expected to produce the same therapeutic effects when used under similar conditions.
Letrozole powder is a fine, crystalline API. This form is used in pharmaceutical manufacturing to create various dosage forms like tablets, capsules, or solutions. Many bodybuilder prefer buying PCT letrozole powder online because it is cheaper than brand-name drug. Buying PCT letrozole powder wholesale can be more cost-effective for manufacturers and researchers.
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3.Letrozole uses
There are many Letrozole for sale online.Letrozole (Femara) PCT ranks as one of the most powerful (and popular) estrogen synthesis inhibitors. Estrogen synthesis inhibitors are also known as Aromatase Inhibitors (AI’s). Here are some of its uses:
Letrozole (Femara) PCT ranks as one of the most powerful (and popular) estrogen synthesis inhibitors. Estrogen synthesis inhibitors are also known as Aromatase Inhibitors (AI’s).
Letrozole use for Breast Cancer Treatment
Letrozole is FDA-approved for use in treating early and advanced hormone-receptor-positive breast cancer in postmenopausal women.
Letrozole use Fertility Treatment
Letrozole is also used off-label to stimulate ovulation in women with polycystic ovary syndrome (PCOS) or other ovulatory disorders. It is often considered when first-line treatments like clomiphene citrate (Clomid) fail.
Letrozole use for Bodybuilding
Letrozole is sometimes used off-label by bodybuilders to manage estrogen levels and prevent gynecomastia (breast tissue growth) associated with anabolic steroid use such as testosterone powder and trenbolone powder.
4.The PCT Uses of Letrozole
Letrozole, is recognized as one of the most potent Aromatase inhibitors (AI). It has found its place in post-cycle therapy (PCT) protocols within bodybuilding. While initially developed as a treatment for breast cancer, its ability to suppress estrogen production has made it a valuable tool for athletes and bodybuilders seeking to manage estrogen-related side effects and restore hormonal balance during PCT. One of the primary uses of Letrozole in PCT is to combat estrogenic side effects that may arise from anabolic steroid use. As some steroids have the potential to aromatize, meaning they can convert into estrogen, the resulting increase in estrogen levels can lead to undesirable effects like water retention, gynecomastia (development of breast tissue in males), and an overall imbalance in hormone levels. By inhibiting the aromatase enzyme responsible for estrogen synthesis, PCT Letrozole powder effectively reduces estrogen levels, mitigating these side effects and promoting a more favorable anabolic environment. Moreover, PCT letrozole powder’s estrogen-lowering properties make it valuable in post-cycle recovery by restoring the hypothalamic-pituitary-gonadal (HPG) axis. Like Clomid, PCT Letrozole powder can help kickstart the body’s natural testosterone production. Reducing estrogen levels prevents estrogen-mediated negative feedback on the hypothalamus and pituitary gland, allowing for increased gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion. This stimulation prompts the testes to produce more testosterone, assisting in the recovery of endogenous testosterone levels after a steroid cycle.
5.What is Aromatase inhibitors (AI) role in bodybuilding?
Are you curious what is Aromatase inhibitors? Aromatase inhibitors (AI) reduce the conversion of androgens to estrogen in the body by inhibiting the enzyme aromatase in the body. Aromatase is an enzyme whose main role is to convert androgens into estrogens. During the use of anabolic androgenic steroids, there is a significant increase in the levels of androgens in the body, which may lead to an increase in estrogen levels as well.
Aromatase inhibitors inhibit the process of converting androgens to estrogens by blocking the activity of the enzyme aromatase. Aromatase inhibitors are often used as part of post-circulatory therapy and are designed to help restore the body’s natural testosterone levels.
6.Why do bodybuilders use PCT letrozole powder? PCT letrozole benefits?
Bodybuilders use PCT powder letrozole primarily for its ability to manage estrogen levels in the body, especially after a cycle of anabolic steroid use. Here are the key reasons why bodybuilders use PCT letrozole powder and its associated benefits:
PCT letrozole powder Prevents Gynecomastia: Anabolic steroids can increase estrogen levels in the body, leading to the development of breast tissue in males (gynecomastia). PCT Letrozole inhibits aromatase, the enzyme responsible for converting androgens into estrogen, thereby reducing estrogen levels and preventing gynecomastia.
PCT Letrozole powder Reduces Water Retention: Elevated estrogen levels can cause water retention, leading to a bloated appearance. By lowering estrogen, PCT powder letrozole helps reduce water retention, promoting a leaner and more defined physique.
PCT powder Letrozole Supports Testosterone Production: Anabolic steroid powder use can suppress natural testosterone production. PCT Letrozole powder helps restore hormonal balance by lowering estrogen levels, which in turn supports the recovery of natural testosterone production post-cycle.
Powder Form: PCT Letrozole is available in powder form, allowing bodybuilders to customize their dosage based on individual needs and response to treatment.
In conclusion, bodybuilders use PCT powder letrozole primarily during post-cycle therapy to Prevents Gynecomastia in men, to reduces Water Retention and to boost their own natural levels of testosterone. Its ability to suppress estrogen production makes it a valuable tool in bodybuilding practices. The important is making sure you buy high quality PCT letrozole powder. Where to buy pure PCT letrozole powder, we will recommend Aea.ltd.
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7.Letrozole Dosage
The letrozole dosages in medical are typical dosages provided by the drug manufacturer. Aea.ltd as PCT letrozole powder supplier, the dosage provide here are only for information.
①Letrozole dosage in Medical use
Letrozole medicine for breast cancer dosage:
The dosage of Femara is the same for all the types of breast cancer the drug treats. You take one tablet by mouth every day. You can take Femara with or without food.
The typical dosage of Femara for all breast cancer uses is 2.5 mg per day. Femara is meant to be used as a long-term treatment. If you and your doctor determine that Femara is safe and effective for you, you’ll likely take it long term.
Letrozole off-label dosage for fertility treatment
The recommended dosage of Femara for fertility treatment is 2.5 milligrams (mg) daily for 5 days. Sometimes 5 mg or 7.5 mg may be prescribed.
It’s important to note that the Food and Drug Administration (FDA) has not approved Femara for fertility treatment. However, the drug is sometimes used off-label for this purpose. Off-label means prescribing a drug in a way that the FDA hasn’t approved.
Femara can be used off-label for fertility treatment when there’s a problem with ovulation (the release of an egg from the ovaries). The drug works to stimulate ovulation. This is called ovulation induction. Femara can also be used when the cause of the fertility problem isn’t known.
If you’d like to learn more about Femara(Letrozole) and fertility treatment, talk with your doctor.
Medicine letrozole dosage for infertility
The standard dosage of Femara for infertility is 2.5 mg daily for 5 days. Infertility means not being able to become pregnant or make someone pregnant. The use of Femara for this purpose is considered off-label.
typical Femara (Letrozole) dosage for treating polycystic ovary syndrome(PCOS)
PCOS is a disorder that can cause problems with hormone levels, periods, and ovarian cysts. Sometimes PCOS affects ovulation, which can make it difficult to get pregnant. The typical dosage of Femara for infertility due to polycystic ovary syndrome (PCOS) is 2.5 mg daily for 5 days.
②PCT Letrozole dosage in bodybuilding
PCT letrozole dosage for gynecomastia
Your doctor would likely not prescribe Femara(Letrozole) for gynecomastia. This is because the FDA has not approved the drug to treat the condition. Gynecomastia, the development of breast tissue in men, is often caused by elevated estrogen levels resulting from anabolic steroid use. The condition is often referred to as “gyno” in bodybuilding. While the FDA has not approved letrozole specifically for the treatment of gynecomastia, many bodybuilders and athletes use it off-label for this purpose.
Letrozole is one of the most potent AIs and is very effective at reducing estrogen levels. It can help prevent and treat gynecomastia by inhibiting the conversion of androgens to estrogen.
To combat gynecomastia aggressively, letrozole is typically started at a higher dose (e.g., 2.5 mg daily) , for a short period (1-2 weeks). After initial suppression, the dose is often tapered to 0.5 mg to 1 mg daily or every other day to maintain lower estrogen levels without causing severe side effects.
In bodybuilding, the best PCT powder for gynecomastia involves a combination of potent aromatase inhibitors like letrozole or anastrozole and selective estrogen receptor modulators like tamoxifen. This combination effectively lowers estrogen levels and blocks estrogen receptors in breast tissue, helping to prevent and treat gynecomastia. Individual responses can vary, it is important to buy high quality PCT powder letrozole powder from reliable manufacturer such as Aea.ltd.
PCT letrozole dosage for water retention
Letrozole is used to reduce water retention caused by elevated estrogen levels, often resulting from anabolic steroid use. A typical starting dose for managing water retention is 0.25 mg to 0.5 mg every other day. This dose can be adjusted based on individual response and the severity of water retention. If water retention persists, the dose can be increased up to 1 mg daily or every other day. It’s crucial to monitor estrogen levels through blood tests to ensure they are effectively lowered without causing excessive suppression.
PCT letrozole dosage for the recovery of natural testosterone production
After discontinuing anabolic steroid use, PCT powder letrozole is used in PCT to support the recovery of natural testosterone production, which is often suppressed during steroid cycles. Typical start with a dose of 0.5 mg to 1 mg every other day initially. This helps to manage estrogen levels while allowing the body to gradually restore natural testosterone production.
8.Alternatives to Letrozole
If letrozole isn’t for you, there are other options. Anastrozole and exemestane are two other aromatase inhibitors worth considering. For Selective Estrogen Receptor Modulators (SERMs) , Clomid and Tamoxifen (Nolvadex) are common alternative.
①Other Aromatase Inhibitors:
PCT Letrozole VS PCT Anastrozole
Anastrozole, like Letrozole, is an AI that reduces estrogen levels by inhibiting aromatase. It is effective in managing gynecomastia by lowering estrogen, thereby preventing the hormonal imbalance that leads to breast tissue development in males. In comparison to Letrozole, Anastrozole has a slightly milder effect on estrogen suppression, which can be advantageous in maintaining a more balanced hormone profile. For natural testosterone recovery, Anastrozole helps by reducing estrogen’s negative feedback on the hypothalamus and pituitary, thus promoting endogenous testosterone production without excessively lowering estrogen levels.
PCT Letrozole VS PCT Exemestane
Exemestane is an irreversible AI that binds permanently to aromatase, reducing estrogen production. Its effectiveness in preventing and treating gynecomastia is comparable to Letrozole and Anastrozole, as it also significantly lowers estrogen levels. The irreversible nature of Exemestane’s action means sustained estrogen suppression, which can be beneficial for long-term gynecomastia prevention. For natural testosterone recovery, Exemestane’s reduction of estrogen-mediated negative feedback helps promote testosterone production. However, the prolonged suppression of estrogen can sometimes be a concern for maintaining hormonal balance.
②Selective Estrogen Receptor Modulators (SERMs):
PCT Letrozole vs PCT Clomiphene (Clomid)
Compared to Letrozole, Clomiphene is a Selective Estrogen Receptor Modulator (SERM) that blocks estrogen receptors in the hypothalamus, stimulating the release of gonadotropins such as LH and FSH. While not as directly effective in reducing estrogen levels as AIs, Clomiphene can help manage gynecomastia indirectly by promoting a balanced hormonal environment. It is highly effective in stimulating natural testosterone production by promoting the release of LH and FSH, crucial for testosterone synthesis, without suppressing overall estrogen levels.
PCT Letrozole VS PCT Tamoxifen (Nolvadex)
Tamoxifen, another SERM, blocks estrogen receptors in breast tissue and the hypothalamus. Compared to Letrozole, it is particularly effective in treating and preventing gynecomastia by directly opposing estrogen’s action in breast tissue. Tamoxifen promotes natural testosterone recovery by stimulating the release of LH and FSH, similar to Clomiphene, and helps maintain a balanced hormonal environment by not reducing systemic estrogen levels. This characteristic makes it a preferred choice for many bodybuilders during PCT, as it addresses both gynecomastia and testosterone recovery effectively.
In summary, while Letrozole, Anastrozole, and Exemestane are potent in reducing estrogen levels and managing gynecomastia, Clomiphene and Tamoxifen excel in supporting natural testosterone recovery by stimulating gonadotropin release. The choice between these compounds depends on individual needs, with AIs being favored for direct estrogen suppression and SERMs for their ability to promote hormonal balance and testosterone production. What is the golden rule to use PCTs in bodybuilding, you can visit this blog for some information.
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9.How do you know letrozole is working?
Knowing if letrozole is working involves monitoring several factors, especially for bodybuilders using it as part of post-cycle therapy (PCT) or for those using it for medical conditions like breast cancer.
For medical conditions, effectiveness can be gauged by a reduction in tumor size seen in imaging studies, decreased hormone levels in blood tests, and improvement in related symptoms such as breast tenderness and swelling.
For bodybuilders, the effectiveness of letrozole in PCT is indicated by a reduction in estrogen-related side effects like gynecomastia, water retention, and fat gain. Regular blood tests to check estradiol and testosterone levels are essential, with a decrease in estrogen and maintained or increased testosterone levels being positive indicators. Physical changes such as reduced water retention and less tender or smaller gynecomastia also suggest that letrozole is working. Additionally, improved mood and energy levels can reflect better hormonal balance. Monitoring for side effects, such as joint pain or fatigue, is important as these should stabilize over time.
10.What is the most common side effect of letrozole?
As with any medication, letrozole can come with side effects. Here are some common ones:
- Weight Gain: Some users notice a bit of weight gain.
- Hair Loss: Thinning hair or hair loss can occur.
- Cholesterol: Letrozole can increase cholesterol levels in the blood, potentially leading to hypercholesterolemia.
- Back Pain: Back pain is a common side effect reported by individuals taking letrozole.
- Bone Density:Letrozole can decrease bone density, increasing the risk of osteoporosis and bone fractures.
- Other Side Effects: Hot flashes, joint pain, fatigue, nausea, and dizziness are also possible.
To avoid unnecessaries side effects, it is very important to take it at the right dosage and buy pure PCT letrozole powder will help you get the maximum benefits of PCT letrozole powder.
11.Is letrozole banned in the US?
Letrozole is FDA-approved drug for the treatment of hormone receptor-positive breast cancer in postmenopausal women. You need to get a prescription to buy letrozole in the pharmacy. It is not FDA-approved if you want to use Letrozole in bodybuilding as a PCT. However, as technology becomes more maturemany, there are many letrozole powder for sale now. People can buy generic Letrozole from the compound pharmacy without prescription. It is well-known that buy Letrozole powder is much cheaper than its brand-name and generic drug. If you want to buy letrozole powder to compound your generic letrozole products, Buy Letrozole powder in bulk will get a good price.
12.Manufacturer of letrozole powder
Letrozole is widely available worldwide, with the Femara brand being the most common. In the U.S., it is not a controlled substance, but a prescription is required to legally obtain it. Additionally, letrozole is often found on the black market through anabolic steroid suppliers. While it is not typically counterfeited, purchasing from these suppliers is illegal in the U.S. despite it not being a controlled substance.
Buying any steroid can be challenging if you do not know a legitimate source. This difficulty also applies when purchasing letrozole powder. One of the simplest and most reliable ways to buy Letrozole is to order it from Aea.ltd. This factory offers PCT Letrozole powcer at affordable cost and ensures that you receive purest letrozole raw.
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Why bodybuilders use letrozole? Letrozole powder form is white or off white crystalline powder, it usually use to make the oral Letrozole pills. Letrozole popular sell in bodybuilding market is because the bodybuilders and athletes who use anabolic steroids might use it to prevent the formation of estrogens, and therefore reduce or prevent the unwanted and feminizing effects of anabolic steroid use.
Do you want to buy letrozole powder from factory and in a competitive price? Aea.ltd is the letrozole powder manufacturer who can supply the purest letrozole powder from grams to kilograms. As one of the best steroid powder manufacturers in 2023, Aea.ltd manufacture the letrozole powder according to cGMP standard strictly, equipped with HPLC, GC, and other analytical instruments. Tests can be done on IR, GC/MS, LC/MS and 400NMR at the SIOC through contract. Our factory have 3×1000KG standard letrozole powder production reactors, monthly synthetic production capacity 1650 KG. QA Operations have been in place for several years to insure that products at our company are prepared responsibly and in accordance with ISO 9001 standards.
Order letrozole powder from this professional steroid powder manufacturer, process is simple and trackable. Your letrozole powder package will be delivery by a safe and discreet method. Send your inquiry and get the high quality letrozole powder online now!
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Aea.ltd is the professional manufacturer of Letrozole(Femara) powder and the production capacity is stable. Our factory will confirm the quality standard before sell, make sure that all letrozole powder which sell to clients is conform the quality standard. We also welcome our clients to test our pure letrozole raw powder at anytime. Here are some testing reports of letrozole powder for reference:
1.Certificate of Analysis-Letrozole Powder
COA-Letrozole Powder(CAS 112809-51-5)
What is COA and What does COA tell you?
A certificate of analysis (CoA) is an essential document in chemical distribution that outlines all the tests performed on a product before it is shipped to a customer. The Certificate of Analysis (CoA) is a contractual document most often issued by a quality control department. It serves to confirm with evidence (analysis results) that a product is tested according to certain standards and methods, and that test results are available.
2.HNMR Report-Letrozole Powder
What is HNMR and What does HNMR tell you?
H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.
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Aea.ltd is the best letrozole powder manufacturers in China and our factory produce high quality letrozole powder in term, we welcomes many requesters and buyers of pure letrozole bulk powder to contact us! Individual users should avoid buying bulk PCT letrozole powder. The advantages of wholesale letrozole bulk powder from Aea.ltd include:
❶Factory production on a large scale, consistent supply, a short delivery cycle, and highprice competitiveness;
❷Provide a quality assurance report for the corresponding batch of quality test report.
❸Professional logistics customization solutions, on-time delivery;
❹Payment methods that are diverse, such as TT and virtual currency;
❺High-quality pre-sales and after-sales service, followed by product and order details consultation.
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1.How to get the quick quote of letrozole/Femara powder online?
Visit professional letrozole powder supplier in China-Aea.ltd website,choose the letrozole powder you want,and leave your contact and message on Aea.ltd website,then submit,Aea.ltd, the customer service will reply you in 12 hours once received your message,then talk in details about letrozole femara powder.
2.Does Aea.ltd support the free sample of letrozole powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for free sample. Welcome our clients test our white pure letrozole powder at any time!
3.What about the wholesale raw letrozole powder packages from Aea.ltd?
Aea.ltd, as a professional raw letrozole powder factory, offers professional packages on raw letrozole bulk powder and adheres to stringent packaging requirements. We utilize a robust aluminum barrel and a double layer aluminum foil bag to pack letrozole powder for bulk wholesale orders, with 25kg per drum and 1kg letrozole powder each bag. Furthermore, we accept customized packaging services based on the needs of our customers.
4.Can I buy discount letrozole powder from Aea.ltd?
Sure, our factory produce high quality letrozole powder in term and keep letrozole powder in stock. Our company has planned promotions on bulk letrozole powder every year. You can buy high quality ferama powder by lower price during promotion sale. You can keep touch with our customer manager and they will update the latest bulk letrozole price for you in time.
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You Might Also Be Concerned About These Issues:
1. Is safe to buy Letrozole in US? |
2. What is Letrozole used for? |
3. Which is better Clomid powder or Letrozole powder? |
4. What is the best time of day to take Letrozole? |
5. How much does letrozole (Femara) cost? |
6. What are alternatives to letrozole (Femara)? |
7. How quickly does Letrozole work? |
8. How to take Letrozole for a man? |
9. Can I buy letrozole powder online directly? |
10. What effects does Letrozole play during bodybuilding? |
As for these questions, please go to the offical website of original drug and see full Prescribing Information and Medication Guide, especially for personal use, please use letrozole (Femara) powder or tablets under the guide of doctor.
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[1] Yang AM, Cui N, Sun YF, Hao GM.”Letrozole for Female Infertility.”Front Endocrinol (Lausanne). 2021 Jun 16;12:676133. doi: 10.3389/fendo.2021.676133. eCollection 2021.PMID: 34220713
[2] Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Hart L, Campone M, Petrakova K, Winer EP, Janni W, Conte P, Cameron DA, André F, Arteaga CL, Zarate JP, Chakravartty A, Taran T, Le Gac F, Serra P, O’Shaughnessy J.”Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer.”N Engl J Med. 2022 Mar 10;386(10):942-950. doi: 10.1056/NEJMoa2114663.PMID: 35263519
[3] Mukherjee AG, Wanjari UR, Nagarajan D, K K V, V A, P JP, T TP, Chakraborty R, Renu K, Dey A, Vellingiri B, Gopalakrishnan AV.”Letrozole: Pharmacology, toxicity and potential therapeutic effects.”Life Sci. 2022 Dec 1;310:121074. doi: 10.1016/j.lfs.2022.121074. Epub 2022 Oct 13.PMID: 36243120
[4] Rugo HS, Finn RS, Diéras V, Ettl J, Lipatov O, Joy AA, Harbeck N, Castrellon A, Iyer S, Lu DR, Mori A, Gauthier ER, Bartlett CH, Gelmon KA, Slamon DJ.”Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up.”Breast Cancer Res Treat. 2019 Apr;174(3):719-729. doi: 10.1007/s10549-018-05125-4. Epub 2019 Jan 10.PMID: 30632023
[5] Bansal S, Goyal M, Sharma C, Shekhar S.”Letrozole versus clomiphene citrate for ovulation induction in anovulatory women with polycystic ovarian syndrome: A randomized controlled trial.”Int J Gynaecol Obstet. 2021 Mar;152(3):345-350. doi: 10.1002/ijgo.13375. Epub 2020 Oct 14.PMID: 32920843
[6] Mejia RB, Summers KM, Kresowik JD, Van Voorhis BJ.”A randomized controlled trial of combination letrozole and clomiphene citrate or letrozole alone for ovulation induction in women with polycystic ovary syndrome.”Fertil Steril. 2019 Mar;111(3):571-578.e1. doi: 10.1016/j.fertnstert.2018.11.030. Epub 2019 Jan 22.PMID: 30683591
[7] Shao YH, Tulandi T.”Letrozole and Unexplained Infertility: A Contemporary Meta-analysis.:J Obstet Gynaecol Can. 2019 Jun;41(6):832-834. doi: 10.1016/j.jogc.2018.12.001. Epub 2019 Jan 31.PMID: 30712904
[8] Sharma P, Chandra R, Sarkar A, Jindal S, Sharma A, Sharma JC, Jaggarwal S.”Assessment of Fertility Outcomes Following Combined Clomiphene and Letrozole Versus Letrozole Therapy for the Treatment of Polycystic Ovarian Syndrome Subfertility.”Cureus. 2023 May 11;15(5):e38886. doi: 10.7759/cureus.38886. eCollection 2023 May.PMID: 37303342
[9] Zhang P, Zhang Q, Tong Z, Sun T, Li W, Ouyang Q, Hu X, Cheng Y, Yan M, Pan Y, Teng Y, Yan X, Wang Y, Xie W, Zeng X, Wang X, Hu C, Geng C, Zhang H, Li W, Wu X, Zhong J, Xu J, Shi Y, Wei W, Bayaxi N, Zhu X, Xu B.”Dalpiciclib plus letrozole or anastrozole versus placebo plus letrozole or anastrozole as first-line treatment in patients with hormone receptor-positive, HER2-negative advanced breast cancer (DAWNA-2): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.”Lancet Oncol. 2023 Jun;24(6):646-657. doi: 10.1016/S1470-2045(23)00172-9. Epub 2023 May 11.PMID: 37182538
[10] Buzdar AU, Robertson JF, Eiermann W, Nabholtz JM.”An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane.”Cancer. 2002 Nov 1;95(9):2006-16. doi: 10.1002/cncr.10908.PMID: 12404296
[11] Marina D, Rasmussen ÅK, Buch-Larsen K, Gillberg L, Andersson M, Schwarz P.”Influence of the anti-oestrogens tamoxifen and letrozole on thyroid function in women with early and advanced breast cancer: A systematic review.”Cancer Med. 2023 Jan;12(2):967-982. doi: 10.1002/cam4.4949. Epub 2022 Jun 24.PMID: 35748065
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