Melanotan II
CAS No.:121062-08-6
Storage Temp:Please seal and store at 8°C–20°C
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| Product Name: | Melanotan II |
| CAS number: | 121062-08-6 |
| Molecular Formula: | C50H69N15O9 |
| Molecular Weight: | 1024.180 |
| Sequence: | Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2 |
| Other names/Synonyms: | Melanotan 2, MT2, MT-2, MT-II |
| Storage Temp: | Please seal and store at 8°C–20°C |
Noted: Please refer to Certificate of Analysis for more information of peptide Melanotan II.
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1.What Is Melanotan II?
Melanotan II (MT-II), also known as MT-2, is a synthetically produced variant of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH), a natural regulator of melanogenesis – the process responsible for skin pigmentation. Acting through melanocortin receptors, Melanotan II not only Stimulates melanin production but also demonstrates effects on metabolism lipid, hunger suppression, and libido enhancement. Originally developed for treating skin conditions, Melanotan II gained popularity for its cosmetic benefits, inducing a tan without UV exposure. The application of destructive effects has been intensively studied.
2.How Does Melanotan II Work?
Melanotan II (MT-II) functions by interacting with specific receptors in the body known as melanocortin receptors, particularly the MC1R and MC4R receptors. Here is a breakdown of how Melanotan II functions:
Stimulation of Melanogenesis: MT-II binds to and activates melanocortin receptors, initiating biochemical reactions within melanocytes. This activation leads to increased melanin production, resulting in skin darkening and a tanning effect.
Activation of Signaling Pathways: MT-II activates signaling pathways involved in melanogenesis, such as the cyclic adenosine monophosphate (cAMP) pathway, crucial for regulating melanin production and distribution.
Sun Protection Effects: The heightened melanin production induced by MT-II provides some protection against UV radiation by absorbing UV rays, mitigating potential damage associated with excessive sun exposure.
Appetite Suppression: MT-II may exert appetite-suppressing effects by interacting with melanocortin receptors, including MC4R receptors, found in the hypothalamus, a brain region associated with appetite regulation.
Lipid Metabolism: Studies suggest that MT-II might influence lipid metabolism, potentially promoting lipolysis (breakdown of fats) and impacting body composition.
Libido Enhancement: MT-II has been reported to have aphrodisiac effects by interacting with melanocortin receptors, particularly MC4R, in brain areas associated with sexual function and libido.
It’s essential to note that the effectiveness and duration of Melanotan II’s tanning effects may vary among individuals due to factors such as genetics, dosage, and frequency of use. Additionally, while Melanotan II may provide some level of sun protection, it is not a substitute for proper sun protection measures, such as wearing sunscreen and limiting UV exposure.
3.Benefits of Peptide Melanotan II
Melanotan II (MT-II) offers several potential benefits, primarily centered around its ability to stimulate melanin production and its effects on certain receptors in the body. Here are some of the key benefits:
Tanning Without Sun Exposure
MT-2 stimulates melanin production in the skin, leading to a tan without the need for extensive sun exposure. This can be beneficial for individuals looking to achieve a tan without risking skin damage from UV radiation.
Sun Protection
The increased melanin levels induced by MT-2 can provide some degree of protection against UV radiation. Melanin absorbs UV rays, potentially reducing the harmful effects of sun exposure on the skin.
Appetite Suppression
MT-2 interacts with melanocortin receptors in the brain, particularly the MC4R receptor in the hypothalamus, which may lead to appetite suppression. This effect can be beneficial for individuals looking to manage their weight or reduce calorie intake.
The appetite-suppressing effects of MT-2 can contribute to weight loss efforts. By reducing appetite, individuals may consume fewer calories, leading to weight loss over time.
Libido Enhancement
Melanocortin receptors are also present in brain regions associated with sexual function. MT-2 may increase sexual desire and libido in some individuals, which can be beneficial for those experiencing low libido or sexual dysfunction.
Treatment of Skin Conditions
MT-2 shows promise in the treatment of certain skin conditions, such as vitiligo and erythropoietic protoporphyria (EPP). Its ability to stimulate melanin production may help improve skin pigmentation in individuals with these conditions.
It is critical to purchase Melanotan II (MT-2) from recognized suppliers; otherwise, you will not achieve the maximum efficacy from it. As a professional Melanotan II manufacturer and supplier, Aea.ltd aims to supply peptide MT-2 all over the world. If you have a need, Aea.ltd’s peptide Melanotan II is an excellent choice.
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4.What Is the Difference Between Melanotan I and Melanotan II
Melanotan I (MT-I) and Melanotan II (MT-II) are both synthetic peptides that mimic the effects of the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH). While they share similarities, there are key differences between the two:
①Receptor Affinity: MT-I primarily binds to the melanocortin 1 receptor (MC1R), which is responsible for regulating melanin production in the skin. In contrast, MT-II has a higher affinity for the melanocortin 4 receptor (MC4R), which is involved in various physiological processes, including sexual function, appetite regulation, and lipid metabolism.
②Effects on Skin Pigmentation: Both peptides stimulate melanin production in the skin, leading to tanning. However, MT-I’s primary action on MC1R results in a more gradual and subtle tan compared to MT-II, which has a stronger and more rapid tanning effect due to its additional actions on MC4R.
③Appetite Suppression and Weight Loss: MT-II’s higher affinity for MC4R gives it stronger appetite-suppressing effects compared to MT-I. This appetite suppression can contribute to weight loss in individuals using MT-II.
④Sexual Function: While both peptides may have some effects on sexual function, MT-II’s specific affinity for MC4R suggests a more pronounced impact on libido, erectile function, and sexual arousal compared to MT-I.
⑤Clinical Applications: MT-I has been studied for its potential medical applications in conditions like erythropoietic protoporphyria (EPP), a rare genetic disorder characterized by extreme sensitivity to sunlight. MT-II, on the other hand, has been investigated for its potential in treating sexual dysfunction and obesity-related conditions.
As a professional peptides manufacturer, Aea.ltd is committed to supply pure Melanotan II vial. If you want to start the Melanotan II journey, go to Aea.ltd without hesitation.
5.Bremelanotide vs. Melanotan II
PT-141 (Bremelanotide) and MT-II (Melanotan II) are both synthetic peptides that affect sexual function but through different mechanisms and with different primary purposes. Here’s a comparison of the two:
Feature | PT-141 (Bremelanotide) | MT-II (Melanotan II) |
Type | Synthetic peptide | Synthetic peptide |
Function | Melanocortin receptor agonist for sexual dysfunction | Melanocortin receptor agonist for tanning and libido |
Target Receptor | MC4R (Melanocortin 4 receptor) | MC1R (Melanocortin 1 receptor) |
Effects | – Increases sexual desire and arousal | – Induces skin pigmentation (tanning) |
– Treats female hypoactive sexual desire disorder | – Suppresses appetite | |
– Addresses erectile dysfunction in men | – May aid in weight loss | |
Dosage Form | Injectable | Injectable |
Safety Profile | Generally well-tolerated, but may cause nausea, flushing, and headache | Generally well-tolerated, but may cause nausea, darkening of moles |
Regulatory Status | Approved by the FDA for the treatment of female HSDD | Not approved by the FDA |
In summary, while both PT-141 and MT-II have effects on sexual function, PT-141 is specifically developed and approved for the treatment of sexual dysfunction, particularly HSDD, while MT-II is primarily used for tanning and has sexual effects as a secondary characteristic. PT-141 acts primarily on the MC4R, while MT-II has a broader receptor profile.
6.Dosage of Melanotan II for Reference
The dosage of Melanotan II (MT-II) can vary depending on factors such as individual response, desired level of tanning, and administration method. However, here are some common dosage guidelines for reference:
Regular Dose (Melanotan II):
- Reconstitute vials with 1 mL of injection water.
- Administer 0.1 mL of Melanotan 2 peptide solution until desired color is reached.
- Maintenance dose: 0.1 mL (1 mcg) once a week.
- Consider a loading phase for new users to minimize side effects.
Loading Dose (Melanotan 2):
- Based on reconstituting vial with 2 mL of water.
- Day 1-3: 0.25 mg/day.
- Day 4-6: 0.5 mg/day.
- Day 7 onwards: Adjust dose based on desired tan depth, up to 1 mcg/day.
As dosages may vary based on individual factors and product specifications, it’s essential to consult reliable sources and consider personal circumstances when determining the appropriate dosage of Melanotan II.
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7.How to Use Peptide Melanotan II?
Melanotan II lyophilized powder in a vial is a common form of the peptide. This form of Melanotan II is popular because it allows for easy storage, transportation, and reconstitution, making it convenient for users. Additionally, lyophilized powder can have a longer shelf life compared to liquid forms of the peptide. To use Melanotan II lyophilized powder in a vial, you will need to reconstitute it with sterile water before administration. Here’s a general guide on how to do it for reference:
①Prepare the Vial: Clean the rubber stopper of the vial with an alcohol wipe to ensure it is sterile.
②Reconstitute the Powder: Using a syringe, inject the appropriate amount of bacteriostatic water or sterile water into the vial. The amount of water needed will depend on the concentration of the powder and your desired dosage. For example, if your vial contains 10 mg of Melanotan II and you want to reconstitute it to a concentration of 1 mg per 0.1 mL, you would add 1 mL of water.
③Mix the Solution: Gently swirl the vial to mix the powder with the water. Do not shake the vial vigorously, as this can cause the solution to foam.
④Withdraw the Solution: Use a fresh, sterile syringe to withdraw the desired dosage of the reconstituted solution. The dosage will depend on your individual needs and the recommendations of your healthcare provider.
⑤Administer the Injection: Clean the injection site with an alcohol swab. Pinch a fold of skin and insert the needle into the fatty tissue. Inject the solution slowly and steadily, then remove the needle and apply pressure to the injection site with a cotton ball or gauze.
⑥Dispose of the Needle Safely: Dispose of the needle in a puncture-proof container, such as a sharps disposal container.
⑦Storage: Store the reconstituted solution in the refrigerator.
Note: Always follow the specific instructions provided with your Melanotan II product and consult with a healthcare professional if you have any questions or concerns about its use. If you want to buy Melanotan II vial with high quality, Aea.ltd is the right place.
8.Side Effects of Peptide Melanotan II
Melanotan II peptide given subcutaneously is reported safe and efficacious in recommended dosages. However, like any drug or substance, Melanotan II may have potential side effects:
- Nausea and Flushing
- Appetite Changes
- Spontaneous penile erections
- Darkening of Moles and Freckles
- Increased Libido
- Hyperpigmentation (Darkened skin)
- Allergic Reactions(itching, rash, or difficulty breathing)
- Fatigue and Dizziness
Note:It is NOT recommended to use PT-141 injection concurrently with a PDE5 inhibitor in men due to the risk of priapism. For your health and safety, when purchasing and using Melanotan II ,please make sure the powder you purchase meets high quality standards. Aea.ltd is committed to providing you with high quality Melanotan II powder( purity over 98% )and ensure the best quality.
9.Where to Buy Peptide Melanotan II?
Melanotan II (MT-II) is becoming more and more well-known due to its capacity to cause skin tanning without requiring a lot of sun exposure. Melanotan II is available for purchase online from various sources now, including peptide suppliers, research chemical websites, and online marketplaces. However, it’s important to exercise caution when buying peptides online, as quality and safety can vary widely among suppliers.
Aea.ltd is your best choice when shopping online. Aea.ltd focuses on providing high-quality Melanotan II raw powder and lyophilized powder in vial. In both forms we guarantee the highest quality Melanotan II products. To ensure your safety, we recommend that you carefully screen and compare extensively to ensure that the choice you make is as reliable as Aea.ltd.
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Melanotan II (MT2) is a peptide injection which stimulates melanin production in the body. Aea.ltd’s Melanotan 2 is a perfect choice for a beautiful and even tan. Our product is a synthetic form of a naturally occurring hormone that plays a crucial role in the pigmentation process. It can help quickly get the results you aim for without any effort. Melanotan 2 kit kits will let you keep your tan for a long period, even if you don’t continue sunbathing. With this product, body will look beautifully tanned all year round.
As a professional peptide manufacturer, Aea.ltd is not only supplies Melanotan vials, but also produces raw Melanotan powder. Aea.ltd factory is equipped with HPLC, GC, and other analytical instruments. Tests can be done on IR, GC/MS, LC/MS and 400NMR at the SIOC through contract. Our fully equipped with many standard reactors and freeze dryers, Melanotan II (MT2) injections and powder production up to 3000 kits monthly. We can provide Melanotan II (MT2) customization for different specifications to match all of your requirements. Perfect quality management system to ensure peptide Melanotan II (MT2) in our company is made at our factory responsibly and in compliance with ISO 9001 standards.
If you need nothing but the best skin tanning agent, Aea.ltd is the best place to buy mt2 peptide. With us, you’re guaranteed to get a 100% genuine and the highest purity Melanotan 2 injections at an excellent price.
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Aea.ltd is the professional manufacturer of Melanotan II to produce top quality peptide Melanotan II pure raw powder and Semi finished Melanotan II in vial, both form can accept customized service. The production capacity is stable, our factory will confirm the quality standard before sell, make sure all Melanotan II powder and Semi finished Melanotan II which sell to clients is conform the quality standard. We also welcome our clients to test this 2 forms of our Melanotan II at anytime. Here are some testing reports of Melanotan II powder for reference:
1.Certificate of Analysis-Melanotan II Powder (CAS:121062-08-6)
COA-Melanotan-II Powder(CAS 121062-08-6)
What is COA and What does COA tell you?
A certificate of analysis (CoA) is an essential document in chemical distribution that outlines all the tests performed on a product before it is shipped to a customer. The Certificate of Analysis (CoA) is a contractual document most often issued by a quality control department. It serves to confirm with evidence (analysis results) that a product is tested according to certain standards and methods, and that test results are available.
2.HPLC Report-Melanotan II Powder (CAS:121062-08-6)
What is HPLC and What does HPLC tell you?
High-performance liquid chromatography (HPLC) is an analytical chemistry technique for separate mixture, quantitative analysis, purity detection and structural identification, this utilize the pressure-driven flow of a mobile phase through a column packed with a stationary phase. The compounds separated in the column are detected by a detector downstream of the column and each compound is identified and quantified. HPLC is widely used in food, chemicals, pharmaceuticals,biological, environmental and agriculture.
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Aea.ltd is the professional manufacturer of the best Melanotan II , our factory produce high quality peptide Melanotan II raw powder and provide customized service on finished vial of Melanotan II , we welcome many requesters and buyers of pure Melanotan II bulk powder to contact us! Individual users should avoid buying bulk Melanotan II powder. The advantages of wholesale Melanotan II products from Aea.ltd include:
❶Factory production on a large scale, consistent supply, a short delivery cycle, and high price competitiveness;
❷Provide a quality assurance report for the corresponding batch of quality test report.
❸Professional logistics customization solutions, on-time delivery;
❹Payment methods that are diverse, such as TT and virtual currency;
❺High-quality pre-sales and after-sales service, followed by product and order details consultation.
1.How to get the quick quote of Melanotan II online?
Visit professional Melanotan II supplier in China-Aea.ltd website, choose the Melanotan II you want, and leave your contact and message on Aea.ltd website, then submit Aea.ltd. The customer service will reply you in 12 hours once received your message,then talk in details about Melanotan II products.
2.Does Aea.ltd support the free sample of Melanotan II powder?
It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for free sample. Welcome our clients test our top quality Melanotan II powder at any time!
3.What form of Melanotan II can I buy from Aea.ltd?
Welcome to order Melanotan II from professional peptide manufacturer Aea.ltd! We can provide 2 forms Melanotan II, the one is Melanotan II pure raw powder, another is Melanotan II lyophilized powder in vial. Our clients can buy Melanotan II from Aea.ltd according to your requests.
4.Can we appoint the cap color of the Melanotan II injection if we buy Melanotan II from Aea.ltd?
Yes, Aea.ltd is the professional peptide manufacturer and also provide CDMO service, accept the request of clients on cap color and our clients can appoint the cap color of Melanotan II if you have bulk order on Melanotan II vials.
5.Can we buy different specification of Melanotan II injection from Aea.ltd?
Sure, Aea.ltd peptide factory always produce different specification of Melanotan II in term according to the request of market. Our clients can buy Melanotan II 5mg, 10mg, 15mg…. from us.
6.How is the Melanotan II packaging? Will the bottle break during shipment?
Aea.ltd, as a professional peptide Melanotan II factory, offers professional packages on all products and adheres to stringent packaging requirements. We package each Melanotan II vial in separate compartments, with 10 in a box to ensure that they do not come into contact with each other during shipment. We also use vacuum packaging to avoid damage caused by shaking and protect the product as much as possible. Furthermore, we accept customized packaging services based on the needs of our customers.
7.Can I buy discount Melanotan II powder from Aea.ltd?
Sure, our factory produce high quality Melanotan II powder in term and keep Melanotan II powder in stock. The more you buy, the more cheaper your price will be. In addition, our company also has planned promotions on bulk Melanotan II powder every year. You can buy high quality Melanotan II powder by lower price during promotion sale. You can keep touch with our customer manager and they will update the latest bulk Melanotan II powder price for you in time.
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You Might Also Be Concerned About These Issues:
| 1.Does Melanotan II work? |
| 2.What is the purpose of using Melanotan II? |
| 3.Does Melanotan II affect kidneys? |
| 4.Does Melanotan II require a prescription? |
| 5.Can Melanotan II cause eye color changes? |
| 6.where can I buy high quality Melanotan II online? |
| 7.Is Melanotan II safe? |
| 8.Can Melanotan II be used for weight loss? |
| 9.How long does it take to see tanning effects? |
| 10.Is Melanotan II safer than tanning beds? |
| 11.How does Melanotan II affect the heart? |
| 12.Is Melanotan II legal? |
As for these questions, please go to the offical website of original drug and see full Prescribing Information and Medication Guide, especially for personal use, please use Melanotan II under the guide of doctor.
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[1] Gilhooley E, Daly S, McKenna D.”Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.”Dermatology. 2021;237(6):995-999. doi: 10.1159/000514492. Epub 2021 Aug 31.PMID: 34464955
[2] Peters B, Hadimeri H, Wahlberg R, Afghahi H.”Melanotan II: a possible cause of renal infarction: review of the literature and case report.”CEN Case Rep. 2020 May;9(2):159-161. doi: 10.1007/s13730-020-00447-z. Epub 2020 Jan 18.PMID: 31953620
[3] Tomassi S, Dimmito MP, Cai M, D’Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S.”CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.”J Med Chem. 2022 Mar 10;65(5):4007-4017. doi: 10.1021/acs.jmedchem.1c01848. Epub 2022 Feb 21.PMID: 35188390
[4] Giuliano F, Clément P, Droupy S, Alexandre L, Bernabé J.”Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat.”Neuroscience. 2006;138(1):293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19.PMID: 16360286
[5] Hjuler KF, Lorentzen HF.”Melanoma associated with the use of melanotan-II.”Dermatology. 2014;228(1):34-6. doi: 10.1159/000356389. Epub 2013 Dec 18.PMID: 24355990
[6] Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML.”Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.”Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E357-E366. doi: 10.1152/ajpendo.00024.2018. Epub 2018 May 29.PMID: 29812984
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