ACE-031

Noted: Please refer to Certificate of Analysis for more information of peptide ACE-031.

1.What is ACE-031?

ACE-031 is a fusion protein of activin receptor type IIB (ActRIIB) and IgG1-Fc developed by Acceleron Pharma, designed to target and block myostatin, promote muscle growth and improve strength. It has great potential in the treatment of muscular dystrophy and other diseases that cause muscle wasting.

Additional content: Myostatin is a natural protein produced by muscle cells and is an important regulator of muscle growth and development. It is able to inhibit the growth and development of muscle cells and prevent excessive muscle development.

2.Mechanism of Action of ACE-031

ACE 031 specifically binds to myostatin and prevents it from interacting with receptors on muscle cells. This allows muscle cells (myocytes) to proliferate and differentiate more freely, promoting muscle growth and maintaining muscle mass.

3.ACE-031 for Duchenne Muscular Dystrophy (DMD)

Duchenne muscular dystrophy (DMD) is a severe genetic disease caused by mutations in the dystrophin gene. The absence or insufficiency of dystrophin leads to muscle cell damage and eventually cell death. DMD results in progressive muscle degeneration and weakness and symptoms that impair their ability to breathe, walk and live independently. This usually appears in boys between the ages of 2-6.

ACE 031 peptide works by inhibiting myostatin, promoting muscle growth and counteracting the muscle atrophy seen in DMD. This could potentially improve muscle function and mobility in affected individuals.

Clinical Trials:

I clinical trial: I clinical trial of Ace-031 was initiated in Canada in September 2008, with results showing a 3.5% increase in muscle volume after 29 days of Ace-031 peptide administration.

II clinical trial: A Phase II clinical trial of Ace 031 was initiated at multiple sites in Canada in April 2010, but it was suspended due to safety concerns. Some participants experienced side effects such as dilation of nasal veins, breast veins, and/or small blood vessels in the skin.

In any case, Ace 031 peptide still provides a new treatment direction for DMD.

4.ACE-031 for Bodybuilding

As a myostatin inhibitor, ace-031 peptide is popular among bodybuilders because of its properties for muscle growth.

①Increase muscle growth 

ACE-031 peptide can achieve greater muscle hypertrophy, thereby increasing muscle size and achieving the purpose of muscle growth

②Enhance recovery:

ACE-031 peptide can promote the activation and proliferation of satellite cells, which can promote rapid muscle recovery. It can facilitate more frequent and intense training for bodybuilders.

③Increase bone density

Increased muscle mass causes bones to bear greater mechanical loads, which may stimulate bone remodeling and increase bone density. Some studies also showed that myostatin may also have an effect on bone metabolism. So in theory, ace-031 peptide can create more favorable conditions for bone formation.

④Enhance strength and endurance

ACE-031 promotes the growth of fast-twitch fibers by inhibiting myostatin. Then it improves the strength and endurance, and thus improves overall training performance.

⑤Fat Loss

ACE-031 peptide increases metabolic efficiency while promoting muscle growth , which can help burn more calories. It also improves insulin sensitivity, which is beneficial for weight management.

5.ACE-031 Side Effects

Although some bodybuilders use ace 031 peptide for muscle gains, it hasn’t been approved for general use yet. Some potential side effects should be to watch out for:

• Nosebleeds
• Bleeding gums
• Pain and swelling at the injection site
• Fatigue
• Increased risk of tumors
• Mild headaches

Some reports showed that serious side effects may appear with high dosage of ACE-031 peptide for a long-time, such as skin discoloration or rash.

6.ACE-031 Dosage

In ACE-031 clinical trials for DMD, patients are usually tested for tolerance starting with an initial ace 031 dosage of 0.5 mg/kg of body weight, and then gradually increased to 3.0 mg/kg

For bodybuilders, the popular ace 031 dose is 1-3 mcg per kilogram of body weight per day for about 15-20 days. For example, a 90kg bodybuilder: ace -031 dosage is 90×2mcg= 180mcg per day. However, it should be noted that ACE-031 peptide use for bodybuilding is not well studied and there are potential health risks. Therefore, please consult a healthcare professional for a specific ACE-031 dose.

7.ACE-031 vs Follistatin 344

Both ACE-031 and Follistatin 344 are part of growth factor and actin regulators. They promote muscle growth by inhibiting myostatin and are being studied for the treatment of muscular dystrophy. However, they have different characteristics and mechanisms of action:

Structure: Follistatin 344 is a natural protein composed of 344 amino acids. ACE-031 is a modified form of Follistatin 344 and specifically designed to inhibit myostatin.

Mechanism: ACE-031 is designed to inhibit myostatin with a stronger and longer-lasting effect; Follistatin 344 works by binding and neutralizing myostatin and other growth factors, which may not be as effective as ACE-031.

Research: ACE-031 is more focused on a specific muscle-wasting disease, while Follistatin 344 has broader applications, including potential performance enhancement.

8.FAQ

①What is ACE-031 peptide half-life?

The half life of Ace-031 is 10-15 days.

②Is ACE-031 legal and approved for use?

ACE-031 peptide is not approved by the FAD for use in humans. It is also banned in sports to enhance performance.

③How is ACE-031 administered?

As the peptide, ACE-031 is usually administered via subcutaneous or intramuscular injection.

④Where to buy ACE-031 peptide online?

There are so many peptide source online, but the most important is to find reliable peptide suppliers with competitive prices. Aea.ltd, as an API CMO& CDMO manufacturer, can provide top-notch ACE-031 peptide with affordable cost. In addition, customized service is also available for special peptide dosage.

ACE-031, a myostatin inhibitor, is structurally a soluble activin receptor form and has significant inhibitory activity, which can effectively inhibit the negative impact of myostatin on muscle mass. ACE-031 is mainly used in the field of scientific research, especially in the areas of amyotrophic diseases, muscle growth and repair.

If you are looking to buy ACE-031 online, you will find many options available. It is crucial to select a reputable supplier to ensure you receive authentic ACE-031, as high-quality products are key to achieving effective results. Aea.ltd, a leading peptide manufacturer, offers pharmaceutical-grade ACE-031 vials and powder. We utilize advanced analytical techniques like GC and HPLC, strictly adhering to cGMP standards in our production processes. Our long-standing quality assurance practices ensure that our products meet ISO 9001 standards.

When you choose Aea.ltd, you can expect not only top-notch products but also exceptional customer service. Your satisfaction is our priority, and we look forward to serving your needs!

Aea.ltd is the professional manufacturer of the best ACE-031, our factory produce high quality peptide ACE 031 raw powder and provide customized service on finished vial of ace-031, we welcome many requesters and buyers of pure ace-031 bulk powder to contact us! Individual users should avoid buying bulk Ace-031 powder. The advantages of wholesale Ace 031 products from Aea.ltd include:

❶Factory production on a large scale, consistent supply, a short delivery cycle, and high price competitiveness;

❷Provide a quality assurance report for the corresponding batch of quality test report.

❸Professional logistics customization solutions, on-time delivery;

❹Payment methods that are diverse, such as TT and virtual currency;

❺High-quality pre-sales and after-sales service, followed by product and order details consultation.

1. How to get the quick quote of ACE-031 online?

Visit professional ace031 supplier in China-Aea.ltd website, choose the ace031 you want, and leave your contact and message on Aea.ltd website, then submit Aea.ltd. The customer service will reply you in 12 hours once received your message,then talk in details about ACE 031 products.

2. Does Aea.ltd support the free sample of ACE-031 powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for free sample. Welcome our clients test our top quality ACE 031 powder at any time!

3.What form of ACE-031 can I buy from Aea.ltd?

Welcome to order ace-031 from professional peptide manufacturer Aea.ltd! We can provide 2 forms ace-031, the one is ace-031 pure raw powder, another is ace-031 lyophilized powder in vial. Our clients can buy Ace-031 from Aea.ltd according to your requests.

4.Can we appoint the cap color of the ACE-031 injection if we buy ACE-031 from Aea.ltd?

Yes, Aea.ltd is the professional peptide manufacturer and also provide CDMO service, accept the request of clients on cap color and our clients can appoint the cap color of ACE031 if you have bulk order on ACE031 vials.  

5.Can we buy different specification of ACE-031 injection from Aea.ltd?

Sure, Aea.ltd peptide factory always produce different specification of ACE 031 in term according to the request of market. Our clients can buy Ace-031 5mg, 10mg, 15mg…. from us.

6.How is the ACE-031 packaging? Will the bottle break during shipment?

Aea.ltd, as a professional peptide Ace-031 factory, offers professional packages on all products and adheres to stringent packaging requirements. We package each Ace-031 vial in separate compartments, with 10 in a box to ensure that they do not come into contact with each other during shipment. We also use vacuum packaging to avoid damage caused by shaking and protect the product as much as possible. Furthermore, we accept customized packaging services based on the needs of our customers.

7. Can I buy discount ACE-031 powder from Aea.ltd?

Sure, our factory produce high quality ace-031 powder in term and keep semaglutide powder in stock. The more you buy, the more cheaper your price will be. In addition, our company also has planned promotions on bulk ace 031 powder every year. You can buy high quality ace-031 powder by lower price during promotion sale. You can keep touch with our customer manager and they will update the latest bulk Ace 031 powder price for you in time.

You Might Also Be Concerned About These Issues:

As for these questions, please go to the official website of original drug and see full Prescribing Information and Medication Guide, especially for personal use, please use ACE-031 under the guide of doctor.

[1] Attie KM, Borgstein NG, Yang Y, Condon CH, Wilson DM, Pearsall AE, Kumar R, Willins DA, Seehra JS, Sherman ML. A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers. Muscle Nerve. 2013 Mar;47(3):416-23. doi: 10.1002/mus.23539. Epub 2012 Nov 21. PMID: 23169607.

[2] Campbell C, McMillan HJ, Mah JK, Tarnopolsky M, Selby K, McClure T, Wilson DM, Sherman ML, Escolar D, Attie KM. Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial. Muscle Nerve. 2017 Apr;55(4):458-464. doi: 10.1002/mus.25268. Epub 2016 Dec 23. PMID: 27462804.

[3] Lee SJ. Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction. J Clin Invest. 2021;131(9):e148372. doi:10.1172/JCI148372

[4] Yaden BC, Wang YX, Wilson JM, et al.  Inhibition of activin A ameliorates skeletal muscle injury and rescues contractile properties by inducing efficient remodeling in female mice. Am J Pathol. 2014;184(4):1152–1166. doi:10.1016/j.ajpath.2013.12.029

[5] Becker C, Lord SR, Studenski SA, et al. STEADY Group. Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial. Lancet Diabetes Endocrinol. 2015;3(12):948–957. doi:10.1016/s2213-8587(15)00298-3.

[6] Woodhouse L, Gandhi R, Warden SJ, et al. ; STUDY INVESTIGATORS. A phase 2 randomized study investigating the efficacy and safety of myostatin antibody LY2495655 versus placebo in patients undergoing elective total hip arthroplasty.

[7] “Decoy Receptor”. Encyclopedia of Cancer. Springer Berlin Heidelberg. 2012. p. 1070. doi:10.1007/978-3-642-16483-5_6693. ISBN 978-3-642-16482-8.

[8] McMahan, CJ; Slack, JL; Mosley, B (1991). “A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types”. The EMBO Journal. 10 (10): 2821–2832. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184

[9] “IL1R2 interleukin 1 receptor, type II [ Homo sapiens (human) ]”. ncbi.nlm.nih.gov. National Center for Biotechnology Information. 2015.

[10] Ashkenazi, Avi (1 June 2002). “Targeting death and decoy receptors of the tumour-necrosis factor superfamily”. Nature Reviews Cancer. 2 (6): 420–430. doi:10.1038/nrc821. PMID 12189384. S2CID 6046465.

[11] Kariolis, Mihalis S (21 September 2014). “An engineered Axl ‘decoy receptor’ effectively silences the Gas6-Axl signaling axis“. Nature Chemical Biology. 10 (11): 977–983. doi:10.1038/nchembio.1636. PMC 4372605. PMID 25242553.

[cusrev_reviews]